The Hoops welcome their rivals to Parkhead on Saturday afternoon hoping to continue their good form and extend their lead at the top of the Scottish Premiership table to four points.
And Griffiths could potentially be a big part of that, after following up his 40-goal return last season with seven goals in nine games so far this term.
The striker had to pull out of the Scotland squad for their opening World Cup qualifier against Malta last week, but was expected to return to fitness for Saturday’s game.
That doesn’t look like being the case at the moment, though, with reports today saying he missed training this morning and is a doubt to play.
As you can understand, there are a lot worried Hoops fans:
Celtic fans – how big a miss would Griffiths be?
Let us know in the comments below..
YOU’LL LOVE OUR PODCAST
We’re joined by former Scotland international Gary Teale to talk the Tartan Army’s win in Malta, what it means, his career and get in about Celtic against Rangers this weekend: