Jose Mourinho’s men went into the game against the La Liga outfit after earning a 0-0 draw in Spain three weeks ago.
So they would have fancied their chances of getting the result they needed to advance to the quarter-finals of the competition.
Unfortunately for United fans, it didn’t turn out that way as Sevilla took a late 2-0 lead through a Wissam Ben Yedder double to force the home side into a very late rally that they were unable to make work.
Romelu Lukaku got a goal back and there were other chances before full-time to get back into it, but United just didn’t have enough quality to bounce back.
And supporters post-match had no doubt about who was to blame, with Mourinho taking the majority of stick for some questionable player selections:
That’s bordering on Arsenal Fan TV, isn’t it?
With that defeat, United now have just one competition left to get a trophy in and that’s the FA Cup.
They’re in the quarter-finals against Brighton at Old Trafford this weekend and will need to quickly bounce back from last night’s disappointment to get through that.
But a club the size of United will expect a lot more going forward from Mourinho and his team.